Blar i forfatter "Hurler, Julia"

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    • The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel 

      Hurler, Julia; Zakelj, Simon; Mravljak, Janez; Pajk, Stane; Kristl, Albin; Schubert, Rolf; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      To study the release of liposome-associated drugs into hydrogels, we designed and synthesized two pH-sensitive rhodamine derivatives to use as model compounds of different lipophilicities. The dyes were fluorescent when in the free form released from liposomes into the chitosan hydrogel, but not when incorporated within liposomes. The effect of liposomal composition, surface charge and vesicle size ...

    • Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle 

      Palac, Zora; Hurler, Julia; Skalko-Basnet, Natasa; Filipovic-Grcic, Jelena; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-14)

    • Liposomes-in-Hydrogel Delivery System with Mupirocin: In Vitro Antibiofilm Studies and In Vivo Evaluation in Mice Burn Model 

      Hurler, Julia; Sørensen, Karen Kristine; Fallalero, Adyary; Vuorela, Pia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Previously, we have proposed mupirocin-in-liposomes-in-hydrogel delivery system as advanced delivery system with the potential in treatment of burns. In the current studies, we evaluated the system for its cytotoxicity, ability to prevent biofilm formation, act on the mature biofilms, and finally determined its potential as wound treatment in in vivo mice burn model.The system was found to be ...

    • Potentials of Chitosan-based Delivery Systems in Wound Therapy: Bioadhesion Study 

      Hurler, Julia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Chitosan is currently proposed to be one of the most promising polymers in wound dressing development. Our research focuses on its potential as a vehicle for nano-delivery systems destined for burn therapy. One of the most important features of wound dressing is its bioadhesion to the wounded site. We compared the bioadhesive properties of chitosan with those of Carbopol, a synthetic origin polymer. ...